Home / Products / 2-Benzhydryl Sulphinyl Acetic Acid
CAS 63547-24-0 Modafinil Metabolite / Impurity Modafinil Metabolite / Impurity High Purity USP Grade EP Grade Reference Standard

2-Benzhydryl Sulphinyl Acetic Acid

IUPAC: (Diphenylmethanesulfinyl)acetic acid View on PubChem
CAS NUMBER
63547-24-0
MOL. FORMULA
C15H14O3S
MOL. WEIGHT
274.33 g/mol
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Scientific Overview

This compound represents the sulfoxide-oxidized carboxylic acid form within the modafinil synthetic and metabolic family --- structurally positioned as the oxidation product of 2-(diphenylmethyl)thioacetic acid, and closely related to modafinil itself (which carries the corresponding amide rather than free carboxylic acid). In vivo, modafinil acid arises from hepatic amidase-mediated hydrolysis of modafinil's amide group, making it a key analyte in pharmacokinetic and forensic toxicology studies of modafinil use.

2-Benzhydrylsulfinylacetic acid, widely known as modafinil acid (or modafinilic acid), is one of the two major human metabolites of modafinil, alongside modafinil sulfone. It also serves as a critical pharmacopeial reference standard (Modafinil Related Compound A) for quality control of modafinil and armodafinil drug substances.

Full Technical Data
Chemical Name 2-Benzhydrylsulfinylacetic Acid (Modafinil Acid / Modafinilic Acid)
CAS Number 63547-24-0
IUPAC Name (Diphenylmethanesulfinyl)acetic acid
Molecular Formula C15H14O3S
Molecular Weight 274.33 g/mol g/mol
Reaction Scheme
2-(Diphenylmethyl)thioacetic Acid
NA
NA
2-Benzhydrylsulfinylacetic Acid (Modafinil Acid)
NA
Commercial Applications

Modafinil/Armodafinil Impurity Reference Standard

Designated as Modafinil Related Compound A for USP/EP-aligned quality control testing.

Bioanalytical & Pharmacokinetic Research

Key analyte for quantifying modafinil metabolism in plasma/urine via LC-MS and HPLC methods.

Forensic Toxicology

Used as a reference standard for screening and confirmation of modafinil use in forensic and doping-control analysis.

Analytical Method Development

Supports HPLC/LC-MS method validation for ANDA submissions and metabolite profiling studies.

Market Therapeutic Focus
MODAFINIL METABOLITE / IMPURITY PHARMACEUTICAL MANUFACTURING CNS / WAKEFULNESS-PROMOTING THERAPEUTICS BIOANALYTICAL & FORENSIC TOXICOLOGY ANALYTICAL REFERENCE STANDARDS CRO/CDMO
Scientific Literature

A Novel Study of Screening and Confirmation of Modafinil, Adrafinil and Their Metabolite Modafinilic Acid

Authors: Various

Indian J. Pharmacol.

DOI: 10.4103/0253-7613.59928

Pharmacokinetic and Pharmacodynamic of the Cognitive Enhancer Modafinil

Authors: Sousa, A.; Dinis-Oliveira, R.J.

Subst. Abuse

DOI: 10.1080/08897077.2019.1700584

Determination of Plasma Levels of Modafinil Enantiomers, Modafinic Acid and Modafinil Sulphone

Authors: Cass, Q.B.; Ferreira Galatti, T.

J. Pharm. Biomed. Anal.

DOI: 10.1016/j.jpba.2007.02.024
Peer Queries & FAQs
Is modafinil acid pharmacologically active?
It is generally considered to have minimal to no significant wake-promoting activity compared to the parent drug, functioning primarily as an inactive metabolite/clearance product.
How is modafinil acid formed in the body?
It results from hepatic amidase-catalyzed hydrolysis of modafinil's amide group, and is one of the two major human metabolites (alongside modafinil sulfone).
Why is this compound important for regulatory testing?
As Modafinil Related Compound A, it is a specified impurity/degradation-related substance that must be quantified in modafinil/armodafinil drug products per compendial standards.
What is the recommended storage condition?
Store in a tightly sealed container at +20°C, protected from light and moisture.

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