This compound represents the sulfoxide-oxidized carboxylic acid form within the modafinil synthetic and metabolic family --- structurally positioned as the oxidation product of 2-(diphenylmethyl)thioacetic acid, and closely related to modafinil itself (which carries the corresponding amide rather than free carboxylic acid). In vivo, modafinil acid arises from hepatic amidase-mediated hydrolysis of modafinil's amide group, making it a key analyte in pharmacokinetic and forensic toxicology studies of modafinil use.
2-Benzhydrylsulfinylacetic acid, widely known as modafinil acid (or modafinilic acid), is one of the two major human metabolites of modafinil, alongside modafinil sulfone. It also serves as a critical pharmacopeial reference standard (Modafinil Related Compound A) for quality control of modafinil and armodafinil drug substances.
| Chemical Name | 2-Benzhydrylsulfinylacetic Acid (Modafinil Acid / Modafinilic Acid) |
| CAS Number | 63547-24-0 |
| IUPAC Name | (Diphenylmethanesulfinyl)acetic acid |
| Molecular Formula | C15H14O3S |
| Molecular Weight | 274.33 g/mol g/mol |
Designated as Modafinil Related Compound A for USP/EP-aligned quality control testing.
Key analyte for quantifying modafinil metabolism in plasma/urine via LC-MS and HPLC methods.
Used as a reference standard for screening and confirmation of modafinil use in forensic and doping-control analysis.
Supports HPLC/LC-MS method validation for ANDA submissions and metabolite profiling studies.
Indian J. Pharmacol.
Subst. Abuse
J. Pharm. Biomed. Anal.
Our R&D centers specialize in the design and process development of complex heterocyclic and chiral molecules — mg to kg scale.