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CAS 863-57-0 Glycine-Conjugated Bile Salt (Absorption Enhancer) Glycine-Conjugated Bile Salt (Absorption Enhancer)

Sodium Glycocholate

IUPAC: Sodium N-(3a,7a,12a-trihydroxy-5ß-cholan-24-oyl)glycinate View on PubChem
CAS NUMBER
863-57-0
MOL. FORMULA
C26H42NNaO6
MOL. WEIGHT
487.61 g/mol
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Scientific Overview

Its high water solubility and strong micelle-forming ability at physiologically relevant pH make sodium glycocholate a key ingredient in biorelevant dissolution media (such as FaSSIF/FeSSIF) used to simulate intestinal fluid during formulation development, as well as a studied intestinal permeation enhancer for oral peptide and macromolecule drug delivery.

Sodium Glycocholate is the sodium salt of glycocholic acid, a highly water-soluble conjugated bile salt used as a permeation/absorption enhancer in oral drug delivery systems and as a biosimulant medium component for dissolution testing.

Full Technical Data
Chemical Name Sodium Glycocholate
CAS Number 863-57-0
IUPAC Name Sodium N-(3a,7a,12a-trihydroxy-5ß-cholan-24-oyl)glycinate
Molecular Formula C26H42NNaO6
Molecular Weight 487.61 g/mol g/mol
Reaction Scheme
Glycocholic Acid
Sodium Hydroxide
NA
Sodium Glycocholate
NA
Commercial Applications

Biorelevant Dissolution Media Component

Key bile-salt component of FaSSIF/FeSSIF simulated intestinal fluid formulations for in vitro dissolution testing.

Oral Peptide/Macromolecule Absorption Enhancer

Studied as an intestinal permeation enhancer for oral delivery of peptides and other poorly permeable APIs.

Membrane Protein Solubilization

Used as a mild anionic detergent for membrane protein extraction and reconstitution studies.

Cholesterol & Lipid Solubility Research

Used in research on cholesterol gallstone formation and lipid micelle solubilization.

Market Therapeutic Focus
GLYCINE-CONJUGATED BILE SALT (ABSORPTION ENHANCER) PHARMACEUTICAL MANUFACTURING ORAL PEPTIDE/MACROMOLECULE DELIVERY BIORELEVANT DISSOLUTION TESTING ANALYTICAL REFERENCE STANDARDS CRO/CDMO
Scientific Literature

Advances in the Design of Fasted State Simulating Intestinal Fluids: FaSSIF-V3

Authors: Fuchs, A. et al.

Eur. J. Pharm. Biopharm.

DOI: 10.1016/j.ejpb.2015.05.015

Bile Salts as Intestinal Permeation Enhancers for Oral Peptide Delivery

Authors: Maher, S. et al.

Adv. Drug Deliv. Rev.

DOI: 10.1016/j.addr.2016.01.010

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

Authors: Lefebvre, P. et al.

Physiol. Rev.

DOI: 10.1152/physrev.00010.2008
Peer Queries & FAQs
What is FaSSIF and why does it contain Sodium Glycocholate?
FaSSIF (Fasted State Simulating Intestinal Fluid) is a standardized biorelevant dissolution medium that includes sodium glycocholate and lecithin to mimic the bile-salt micelle environment of the human small intestine for realistic in vitro drug dissolution testing.
How does Sodium Glycocholate act as an absorption enhancer?
It can transiently increase intestinal epithelial permeability and form mixed micelles that improve the apparent solubility and membrane transit of co-administered poorly absorbed drugs.
Is Sodium Glycocholate the same as SNAC?
No, they are chemically distinct absorption-enhancer classes; Sodium Glycocholate is a natural conjugated bile salt, while SNAC (Salcaprozate Sodium) is a synthetic small-molecule permeation enhancer.
What is the recommended storage condition?
Store in a tightly sealed container at 2-8°C, protected from moisture, as the material is hygroscopic.

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