Sodium caprylate's stabilizing mechanism in albumin manufacturing works by binding to specific sites on the albumin molecule, protecting its native conformation from heat-induced denaturation during the pasteurization step required for viral inactivation in blood-derived products. Separately, in monoclonal antibody purification, sodium caprylate (as NaCA) is used post-Protein A chromatography to selectively precipitate host cell proteins and promote their removal, while also serving as an albumin-selective modifier in hydrophobic charge-induction chromatography (HCIC) to improve IgG purification selectivity.
Sodium Caprylate (sodium octanoate) is the sodium salt of caprylic acid, a medium-chain fatty acid. It plays a dual critical role in the biopharmaceutical industry: as a stabilizer preserving the biological activity of human albumin solutions during pasteurization, and as a host cell protein (HCP) clearance aid in monoclonal antibody downstream purification.
| Chemical Name | Sodium Caprylate (Sodium Octanoate) |
| CAS Number | 1984-06-1 |
| IUPAC Name | Sodium octanoate |
| Molecular Formula | C8H15NaO2 |
| Molecular Weight | 166.19 g/mol g/mol |
Used as a stabilizer to protect human albumin solutions from heat denaturation during viral-inactivation pasteurization.
Applied as a host cell protein precipitation aid post-Protein A chromatography and as a selectivity modifier in HCIC-based IgG purification.
Studied as a permeation enhancer to improve oral bioavailability of peptide-based drug candidates.
Used for pathogen inactivation applications, including studied use against E. coli O157:H7 in agricultural water treatment contexts.
Protein Expr. Purif.
J. Chromatogr. A
Protein Expr. Purif.
Our R&D centers specialize in the design and process development of complex heterocyclic and chiral molecules — mg to kg scale.