Home / Products / Sodium Deoxycholate
CAS 302-95-4 Secondary Bile Salt (Ionic Detergent) Secondary Bile Salt (Ionic Detergent)

Sodium Deoxycholate

IUPAC: Sodium 3a,12a-dihydroxy-5ß-cholan-24-oate View on PubChem
CAS NUMBER
302-95-4
MOL. FORMULA
C24H39NaO4
MOL. WEIGHT
414.55 g/mol
Get Commercial Quote Request Sample Request COA
Scientific Overview

As a stronger detergent than cholate (owing to one fewer hydroxyl group), sodium deoxycholate more aggressively disrupts lipid membranes, making it effective for both cell lysis/protein extraction protocols and, in its purified injectable form (as deoxycholic acid), for adipocyte membrane disruption in cosmetic submental fat reduction treatments.

Sodium Deoxycholate is the sodium salt of deoxycholic acid, a secondary bile acid formed by bacterial 7a-dehydroxylation of cholic acid, widely used as an anionic detergent for cell lysis, membrane protein extraction, and as an FDA-approved injectable for submental fat reduction.

Full Technical Data
Chemical Name Sodium Deoxycholate
CAS Number 302-95-4
IUPAC Name Sodium 3a,12a-dihydroxy-5ß-cholan-24-oate
Molecular Formula C24H39NaO4
Molecular Weight 414.55 g/mol g/mol
Reaction Scheme
Cholic Acid (via bacterial or chemical 7a-dehydroxylation)
Sodium Hydroxide
NA
Sodium Deoxycholate
NA
Commercial Applications

Cell Lysis & Protein Extraction

Ionic detergent used in RIPA and related lysis buffers for protein extraction and immunoprecipitation.

Membrane Receptor Solubilization

Extracts plasma membrane receptors and proteins for purification and structural studies.

Microbiological Selective Media Component

Used as a selective/inhibitory agent in bacteriological culture media formulations.

Viral Membrane Disruption Research

Used experimentally to inactivate enveloped viruses and fractionate viral membrane components.

Market Therapeutic Focus
SECONDARY BILE SALT (IONIC DETERGENT) PHARMACEUTICAL MANUFACTURING MEMBRANE PROTEIN RESEARCH DIAGNOSTICS & IMMUNOASSAYS ANALYTICAL REFERENCE STANDARDS CRO/CDMO
Scientific Literature

Deoxycholic Acid Injection for Submental Fat Reduction: A Review

Authors: Humphrey, S. et al.

Aesthet. Surg. J.

DOI: 10.1177/1090820X17722688

Cholate-Based Detergents for Membrane Protein Solubilization

Authors: Le Maire, M. et al.

Biochim. Biophys. Acta

DOI: 10.1016/S0304-4157(00)00016-2

Sodium Deoxycholate Solubilization of Viral Membranes

Authors: Helenius, A.; Simons, K.

Biochim. Biophys. Acta

DOI: 10.1016/0304-4157(75)90016-7
Peer Queries & FAQs
How is Sodium Deoxycholate different from Sodium Cholate?
Deoxycholate has one fewer hydroxyl group than cholate (a secondary rather than primary bile acid), making it a stronger, more membrane-disruptive detergent.
Is Sodium Deoxycholate related to the injectable cosmetic treatment for double chin?
Yes, purified deoxycholic acid (the free-acid form) is the active ingredient in FDA-approved injectable treatments for submental fat reduction; the sodium salt form is used as a laboratory detergent reagent.
Why is it used in RIPA lysis buffer?
Its detergent action, combined with SDS and Triton X-100, efficiently solubilizes both membrane and nuclear proteins for downstream Western blot and immunoprecipitation analysis.
What is the recommended storage condition?
Store in a tightly sealed container at room temperature, protected from moisture.

Need a Custom Derivative or Labeled Analog?

Our R&D centers specialize in the design and process development of complex heterocyclic and chiral molecules — mg to kg scale.

Request Custom Synthesis Quote Check Manufacturing Scale